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Genetic factors related to alcohol problems were more pronounced under conditions of low parental knowledge and high peer deviance. When environmental measures are not available in a case-control sample, association between genetic factors underlying the disease and the potential environmental moderator can be studied in samples with healthy individuals. Power et al. ( 2014 ) used GRPS for schizophrenia risk (Ripke et al.
This result does not exclude the possibility of a causal relationship but shows that at least part of the association between schizophrenia and cannabis use may be due to a shared genetic aetiology.